BAIT
PRKCD
AI385711, D14Ertd420e, PKC[d], PKCdelta, Pkcd
protein kinase C, delta
GO Process (35)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- B cell proliferation [IMP]
- apoptotic process [ISO]
- aspartate transport [ISO]
- cellular senescence [ISO]
- collagen metabolic process [ISO]
- defense response to bacterium [IMP]
- immunoglobulin mediated immune response [IMP]
- interleukin-10 production [IMP]
- interleukin-12 production [IMP]
- intracellular signal transduction [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of actin filament polymerization [IMP]
- negative regulation of filopodium assembly [IMP]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP]
- negative regulation of platelet aggregation [IMP]
- neutrophil activation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of ceramide biosynthetic process [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucosylceramide catabolic process [ISO]
- positive regulation of phospholipid scramblase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of sphingomyelin catabolic process [ISO]
- positive regulation of superoxide anion generation [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to oxidative stress [ISO]
- termination of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAPK1
9030612K14Rik, AA407128, AU018647, C78273, ERK, Erk2, MAPK2, PRKM2, Prkm1, p41mapk, p42mapk
mitogen-activated protein kinase 1
GO Process (35)
GO Function (12)
GO Component (18)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IDA, IMP, ISO]
- MAPK import into nucleus [ISO]
- T cell receptor signaling pathway [IDA]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to organic substance [ISO]
- cytosine metabolic process [IDA]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- lipopolysaccharide-mediated signaling pathway [IDA]
- mammary gland epithelial cell proliferation [IDA]
- negative regulation of cell differentiation [IGI]
- organ morphogenesis [IDA]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [NAS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO]
- response to estrogen [ISO]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to toxic substance [ISO]
- sensory perception of pain [ISO]
- signal transduction [ISO]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [ISO]
- caveola [TAS]
- cytoplasm [IDA, ISO]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [ISO]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [IDA, TAS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, TAS]
- perikaryon [ISO]
- protein complex [ISO]
- pseudopodium [IDA]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.736 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID