BAIT
PRKCA
AI875142, Pkca, RP23-145G23.2
protein kinase C, alpha
GO Process (51)
GO Function (7)
GO Component (18)
Gene Ontology Biological Process
- cellular calcium ion homeostasis [IMP]
- cellular response to carbohydrate stimulus [IDA]
- central nervous system neuron axonogenesis [ISO]
- chondrocyte differentiation [IDA]
- desmosome assembly [ISO]
- histone H3-T6 phosphorylation [ISO]
- inactivation of MAPK activity [IMP]
- induction of positive chemotaxis [IMP]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway [IMP]
- learning or memory [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of glucose import [IMP]
- negative regulation of heart contraction [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IGI, IMP]
- negative regulation of translation [ISO]
- neutrophil chemotaxis [IMP]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of dense core granule biogenesis [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of exocytosis [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [ISO]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synapse assembly [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of muscle contraction [IMP]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- regulation of platelet aggregation [IMP, ISO]
- regulation of receptor-mediated endocytosis [ISO]
- regulation of the force of heart contraction [IMP]
- response to estradiol [ISO]
- response to ethanol [ISO]
- response to interleukin-1 [ISO]
- response to reactive oxygen species [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [IDA]
- cell [IMP]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrion [IDA, ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- photoreceptor outer segment [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
Mus musculus
PREY
MAPK3
Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3, p44, p44erk1, p44mapk
mitogen-activated protein kinase 3
GO Process (35)
GO Function (6)
GO Component (15)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- DNA damage induced protein phosphorylation [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [ISO]
- cartilage development [IDA]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- interleukin-1-mediated signaling pathway [ISO]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of apolipoprotein binding [IMP]
- organ morphogenesis [IDA]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-tyrosine autophosphorylation [ISO]
- phosphorylation [ISO, TAS]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of translation [ISO]
- protein complex assembly [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to toxic substance [ISO]
- sensory perception of pain [IMP]
- signal transduction [TAS]
- transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- caveola [TAS]
- cytoplasm [IDA]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [TAS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, TAS]
- protein complex [ISO]
- pseudopodium [IDA]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7695 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID