YWHAH
Gene Ontology Biological Process
- cytoskeleton organization [NAS]
- glucocorticoid catabolic process [ISO]
- glucocorticoid receptor signaling pathway [ISO]
- intracellular protein transport [IDA]
- membrane depolarization during action potential [ISO, ISS]
- negative regulation of apoptotic process [NAS]
- negative regulation of dendrite morphogenesis [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of mitosis [NAS]
- regulation of sodium ion transmembrane transporter activity [ISO, ISS]
- regulation of sodium ion transport [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MARK2
Gene Ontology Biological Process
- establishment of cell polarity [ISO]
- establishment or maintenance of epithelial cell apical/basal polarity [ISO]
- intracellular signal transduction [ISO]
- neuron migration [ISO]
- positive regulation of neuron projection development [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of axonogenesis [ISO]
- regulation of cytoskeleton organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.933 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YWHAH MARK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| MARK2 YWHAH | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID