BAIT
CALR
CRT, Calregulin
calreticulin
GO Process (22)
GO Function (13)
GO Component (21)
Gene Ontology Biological Process
- cell cycle arrest [ISO]
- cellular senescence [IMP, ISO]
- chaperone-mediated protein folding [ISO]
- cortical actin cytoskeleton organization [IDA]
- negative regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of retinoic acid receptor signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of translation [ISO]
- peptide antigen assembly with MHC class I protein complex [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of cell cycle [IMP, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of dendritic cell chemotaxis [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein export from nucleus [ISO]
- protein localization to nucleus [IMP, ISO]
- protein stabilization [IDA]
- regulation of meiosis [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MHC class I peptide loading complex [IMP]
- acrosomal vesicle [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO, ISS]
- endoplasmic reticulum lumen [IDA, ISO]
- external side of plasma membrane [IDA]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- polysome [IDA]
- protein complex [ISO]
- sarcoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
PREY
NPM1
B23, NO38, Npm, RP23-323L8.2
nucleophosmin 1
GO Process (39)
GO Function (18)
GO Component (16)
Gene Ontology Biological Process
- DNA repair [ISO]
- cell aging [ISO]
- cell growth [IDA]
- cell volume homeostasis [IDA, IMP]
- centrosome cycle [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of centrosome duplication [ISO]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [ISO]
- nucleocytoplasmic transport [IDA, ISO]
- nucleosome assembly [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cellular biosynthetic process [IDA, IMP]
- positive regulation of centrosome duplication [IGI]
- positive regulation of protein kinase activity [IDA]
- positive regulation of translation [ISO]
- protein destabilization [IMP]
- protein homooligomerization [ISO]
- protein localization [IMP, ISO]
- protein oligomerization [ISO]
- rRNA export from nucleus [IDA, IMP]
- regulation of DNA damage response, signal transduction by p53 class mediator [IGI]
- regulation of cell cycle [IMP]
- regulation of centriole replication [ISO]
- regulation of centrosome duplication [IMP]
- regulation of eIF2 alpha phosphorylation by dsRNA [ISO]
- regulation of endodeoxyribonuclease activity [ISO]
- regulation of endoribonuclease activity [ISO]
- regulation of neuron apoptotic process [ISO]
- response to stress [ISO]
- ribosomal large subunit biogenesis [IDA, IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit biogenesis [IDA, IMP]
- ribosomal small subunit export from nucleus [IDA]
Gene Ontology Molecular Function- DNA binding [ISO]
- NF-kappaB binding [ISO]
- RNA binding [IDA, ISO]
- Tat protein binding [ISO]
- enzyme binding [ISO]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO]
- rRNA binding [IDA]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO]
- DNA binding [ISO]
- NF-kappaB binding [ISO]
- RNA binding [IDA, ISO]
- Tat protein binding [ISO]
- enzyme binding [ISO]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO]
- rRNA binding [IDA]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- cell [IMP]
- centrosome [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- focal adhesion [ISO]
- granular component [IDA]
- intracellular [IMP]
- large ribosomal subunit [IDA]
- membrane [ISO]
- nuclear speck [IDA]
- nucleolus [IDA, ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- ribonucleoprotein complex [ISO]
- small ribosomal subunit [IDA]
- spindle pole centrosome [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.709 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID