BAIT
CNTN2
D130012K04Rik, TAG-1, Tax
contactin 2
GO Process (24)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- adult walking behavior [IMP]
- axon guidance [IGI, IMP]
- axonal fasciculation [IMP]
- axonogenesis [ISO]
- cell-matrix adhesion [ISO]
- cellular protein localization [IMP]
- central nervous system myelination [IMP]
- cerebral cortex GABAergic interneuron migration [IMP]
- clustering of voltage-gated potassium channels [IMP]
- establishment of protein localization to juxtaparanode region of axon [IDA]
- learning [IMP]
- microtubule cytoskeleton organization [IMP]
- negative regulation of neuron differentiation [IGI]
- neuron migration [IMP]
- neuron projection development [IGI]
- positive regulation of adenosine receptor signaling pathway [IMP]
- positive regulation of protein processing [IDA]
- presynaptic membrane organization [ISO]
- protein localization to juxtaparanode region of axon [IGI, IMP]
- receptor internalization [IDA]
- regulation of astrocyte differentiation [IMP]
- regulation of axon diameter [IMP]
- regulation of cell morphogenesis involved in differentiation [IMP]
- regulation of neuronal synaptic plasticity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NRCAM
Bravo, C030017F07Rik, C130076O07Rik, mKIAA0343
neuronal cell adhesion molecule
GO Process (9)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- axon guidance [IDA]
- central nervous system development [IDA]
- clustering of voltage-gated sodium channels [IMP, ISO]
- heterotypic cell-cell adhesion [IGI]
- neuronal action potential propagation [IMP]
- protein localization [IDA]
- regulation of neuron projection development [IMP]
- retinal ganglion cell axon guidance [IMP]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.816 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID