BAIT
GIT1
Cat-1, p95Cat, RP23-81E16.3
G protein-coupled receptor kinase-interactor 1
GO Process (5)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PAK2
5330420P17Rik, A130002K10Rik, AI836325, D16Ertd269e, PAK-2, mKIAA4182
p21 protein (Cdc42/Rac)-activated kinase 2
GO Process (15)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- cytokinesis [IBA]
- intracellular signal transduction [IBA]
- mitotic cell cycle [IBA]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO, ISS]
- regulation of apoptotic process [IBA]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IBA, ISO]
- nucleoplasm [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7605 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID