BAIT
PDHX
AI481367, E3bp, Pdx1, RP23-203N8.2
pyruvate dehydrogenase complex, component X
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Mus musculus
PREY
PDK2
RP23-112C19.5
pyruvate dehydrogenase kinase, isoenzyme 2
GO Process (12)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- cellular response to nutrient [IMP]
- cellular response to reactive oxygen species [ISO]
- glucose homeostasis [IMP]
- insulin receptor signaling pathway [IMP]
- intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- peptidyl-serine phosphorylation [ISO]
- protein phosphorylation [IMP, ISO]
- regulation of acetyl-CoA biosynthetic process from pyruvate [IMP]
- regulation of cellular ketone metabolic process [IMP]
- regulation of gluconeogenesis [IMP]
- regulation of glucose metabolic process [IMP]
- regulation of pH [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.861 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID