BAIT
APOA1
Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep-2, Sep2, apo-AI, apoA-I
apolipoprotein A-I
GO Process (53)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adrenal gland development [IMP]
- axon regeneration [IGI]
- blood vessel endothelial cell migration [IMP]
- cholesterol biosynthetic process [IMP]
- cholesterol efflux [IDA, IMP, ISO]
- cholesterol homeostasis [IBA, ISO]
- cholesterol import [ISO]
- cholesterol metabolic process [IGI, IMP, ISO]
- cholesterol transport [IDA, IMP, ISO]
- endothelial cell proliferation [IMP]
- glucocorticoid metabolic process [IMP]
- high-density lipoprotein particle assembly [IBA, ISO]
- integrin-mediated signaling pathway [ISO]
- lipid storage [IMP]
- lipoprotein biosynthetic process [IGI, IMP]
- negative chemotaxis [ISO]
- negative regulation of cell adhesion molecule production [ISO]
- negative regulation of cytokine secretion involved in immune response [ISO]
- negative regulation of heterotypic cell-cell adhesion [ISO]
- negative regulation of hydrolase activity [IGI]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-1 beta secretion [ISO]
- negative regulation of lipase activity [ISO]
- negative regulation of response to cytokine stimulus [ISO]
- negative regulation of tumor necrosis factor-mediated signaling pathway [ISO]
- negative regulation of very-low-density lipoprotein particle remodeling [ISO]
- organ regeneration [ISO]
- peptidyl-methionine modification [ISO]
- phosphatidylcholine biosynthetic process [ISO]
- phosphatidylcholine metabolic process [IBA]
- phospholipid efflux [IBA, ISO]
- phospholipid homeostasis [ISO]
- phospholipid metabolic process [IMP]
- phospholipid transport [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cholesterol esterification [IBA, ISO]
- positive regulation of fatty acid biosynthetic process [IBA]
- positive regulation of hydrolase activity [ISO]
- positive regulation of lipoprotein lipase activity [IBA]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- positive regulation of transferase activity [IMP]
- positive regulation of triglyceride catabolic process [IBA]
- protein localization [IMP]
- protein oxidation [ISO]
- protein stabilization [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of intestinal cholesterol absorption [IDA]
- regulation of protein phosphorylation [IDA]
- reverse cholesterol transport [IBA, ISO]
- triglyceride homeostasis [IBA, ISO]
- very-low-density lipoprotein particle remodeling [IBA]
Gene Ontology Molecular Function- apolipoprotein A-I receptor binding [ISO]
- apolipoprotein receptor binding [ISO]
- beta-amyloid binding [ISO]
- chemorepellent activity [ISO]
- cholesterol binding [IBA, ISO]
- cholesterol transporter activity [IDA, ISO]
- enzyme binding [ISO]
- high-density lipoprotein particle binding [IDA]
- high-density lipoprotein particle receptor binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- lipase inhibitor activity [ISO]
- lipid binding [IDA]
- lipid transporter activity [IDA, IMP]
- lipoprotein particle binding [IDA]
- phosphatidylcholine binding [IBA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
- phospholipid binding [ISO]
- phospholipid transporter activity [ISO]
- protein binding [IPI]
- apolipoprotein A-I receptor binding [ISO]
- apolipoprotein receptor binding [ISO]
- beta-amyloid binding [ISO]
- chemorepellent activity [ISO]
- cholesterol binding [IBA, ISO]
- cholesterol transporter activity [IDA, ISO]
- enzyme binding [ISO]
- high-density lipoprotein particle binding [IDA]
- high-density lipoprotein particle receptor binding [IBA, ISO]
- identical protein binding [IPI, ISO]
- lipase inhibitor activity [ISO]
- lipid binding [IDA]
- lipid transporter activity [IDA, IMP]
- lipoprotein particle binding [IDA]
- phosphatidylcholine binding [IBA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
- phospholipid binding [ISO]
- phospholipid transporter activity [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- blood microparticle [IBA, ISO]
- cell surface [ISO]
- chylomicron [IBA]
- cytoplasmic vesicle [ISO]
- discoidal high-density lipoprotein particle [ISO]
- endocytic vesicle [ISO]
- extracellular region [IDA]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- high-density lipoprotein particle [IBA, ISO]
- nucleus [ISO]
- spherical high-density lipoprotein particle [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Mus musculus
PREY
PDPK1
Pdk1, RP23-153H18.1
3-phosphoinositide dependent protein kinase 1
GO Process (23)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- activation of protein kinase B activity [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to insulin stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- focal adhesion assembly [ISO]
- hyperosmotic response [IDA]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of protein kinase activity [ISO]
- negative regulation of toll-like receptor signaling pathway [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of phospholipase activity [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of endothelial cell migration [IMP]
- regulation of mast cell degranulation [IMP]
- signal transduction [TAS]
- type B pancreatic cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.844 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID