BAIT
FAM213B
2810405K02Rik, AI836168, PM/PGFS, RP23-15L19.6
family with sequence similarity 213, member B
GO Process (2)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PDPK1
Pdk1, RP23-153H18.1
3-phosphoinositide dependent protein kinase 1
GO Process (23)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- activation of protein kinase B activity [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to insulin stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- focal adhesion assembly [ISO]
- hyperosmotic response [IDA]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of protein kinase activity [ISO]
- negative regulation of toll-like receptor signaling pathway [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of phospholipase activity [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of endothelial cell migration [IMP]
- regulation of mast cell degranulation [IMP]
- signal transduction [TAS]
- type B pancreatic cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.8195 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID