NCKAP1
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- apical protein localization [IDA]
- basal protein localization [IDA]
- cell migration involved in gastrulation [IMP]
- embryonic body morphogenesis [IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic heart tube development [IMP]
- endoderm development [IMP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- in utero embryonic development [IMP]
- lamellipodium assembly [IDA, IMP]
- mesodermal cell migration [IMP]
- neural tube closure [IMP]
- notochord development [IMP]
- notochord morphogenesis [IMP]
- paraxial mesoderm development [IMP]
- paraxial mesoderm morphogenesis [IMP]
- positive regulation of Arp2/3 complex-mediated actin nucleation [ISO]
- positive regulation of lamellipodium assembly [ISO]
- protein stabilization [IMP]
- regulation of protein localization [IMP]
- somitogenesis [IMP]
- zygotic determination of anterior/posterior axis, embryo [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PFN2
Gene Ontology Biological Process
- negative regulation of actin filament polymerization [IDA, ISO]
- negative regulation of epithelial cell migration [IMP, ISO]
- negative regulation of ruffle assembly [IMP, ISO]
- positive regulation of ATPase activity [ISO]
- positive regulation of actin filament bundle assembly [ISO]
- positive regulation of actin filament polymerization [IMP, ISO]
- positive regulation of peptidyl-serine phosphorylation [IMP, ISO]
- positive regulation of stress fiber assembly [IMP, ISO]
- regulation of synaptic vesicle exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.9535 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PFN2 NCKAP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID