BAIT
HSD17B4
17-beta-HSD, 17[b]-HSD, 4, DBP, MFE-2, MFP2, MPF-2, Mfp-2, perMFE-2
hydroxysteroid (17-beta) dehydrogenase 4
GO Process (10)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- Sertoli cell development [IMP]
- androgen metabolic process [ISO]
- estrogen metabolic process [ISO]
- fatty acid beta-oxidation [IMP, ISO]
- medium-chain fatty-acyl-CoA metabolic process [ISO]
- metabolic process [ISO]
- osteoblast differentiation [ISO]
- oxidation-reduction process [ISO]
- very long-chain fatty acid metabolic process [IMP]
- very long-chain fatty-acyl-CoA metabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PLEK
2010300B13Rik, RP23-348N2.1
pleckstrin
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- cell projection organization [ISO]
- cortical actin cytoskeleton organization [ISO]
- integrin-mediated signaling pathway [ISO]
- negative regulation of G-protein coupled receptor protein signaling pathway [ISO]
- negative regulation of inositol phosphate biosynthetic process [ISO]
- phosphatidylinositol metabolic process [ISO]
- phospholipase C-inhibiting G-protein coupled receptor signaling pathway [ISO]
- platelet aggregation [IMP, ISO]
- positive regulation of actin filament bundle assembly [ISO]
- positive regulation of actin filament depolymerization [IMP, ISO]
- positive regulation of inositol-polyphosphate 5-phosphatase activity [ISO]
- positive regulation of integrin activation [IMP]
- positive regulation of platelet activation [IMP]
- protein kinase C signaling [IMP]
- protein secretion by platelet [IMP]
- regulation of cell diameter [ISO]
- ruffle organization [ISO]
- thrombin receptor signaling pathway [IMP, ISO]
- vesicle docking involved in exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.784 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID