BAIT
PCSK2
6330411F23Rik, AI839700, Nec-2, Nec2, PC2, Phpp-2, SPC2, RP23-235A15.4
proprotein convertase subtilisin/kexin type 2
GO Process (7)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PMCH
A230109K23Rik
pro-melanin-concentrating hormone
GO Process (10)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- drinking behavior [ISO]
- feeding behavior [IMP, ISO]
- glucose homeostasis [ISO]
- negative regulation of blood pressure [ISO]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of circadian sleep/wake cycle, REM sleep [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- regulation of heart rate [ISO]
- regulation of neuronal synaptic plasticity [ISO]
- response to cold [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7415 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID