BAIT
GCLC
D9Wsu168e, GLCL-H, Ggcs-hs, Glclc
glutamate-cysteine ligase, catalytic subunit
GO Process (21)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- L-ascorbic acid metabolic process [IMP]
- apoptotic mitochondrial changes [IGI]
- cell redox homeostasis [ISO]
- cysteine metabolic process [ISO]
- glutamate metabolic process [ISO]
- glutathione biosynthetic process [IDA, IMP, ISO]
- glutathione metabolic process [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein ubiquitination [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- regulation of blood vessel size [ISO]
- regulation of mitochondrial depolarization [IGI]
- response to arsenic-containing substance [IMP]
- response to heat [ISO]
- response to hormone [ISO]
- response to nitrosative stress [ISO]
- response to oxidative stress [ISO]
- response to xenobiotic stimulus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PPID
4930564J03Rik, CYP-40, Ppidl, Ppif
peptidylprolyl isomerase D (cyclophilin D)
GO Process (10)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- cellular response to UV-A [ISO]
- chaperone-mediated protein folding [ISO]
- lipid particle organization [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of viral genome replication [ISO]
- protein complex assembly [ISO]
- protein peptidyl-prolyl isomerization [IBA, ISS]
- regulation of apoptotic process [IBA]
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7645 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID