BAIT
SRC
AW259666, pp60c-src, RP23-169M4.1
Rous sarcoma oncogene
GO Process (29)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- bone resorption [IMP]
- branching involved in mammary gland duct morphogenesis [IMP]
- cell migration [IMP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- epidermal growth factor receptor signaling pathway [IBA]
- forebrain development [IGI]
- innate immune response [IBA]
- intracellular signal transduction [IGI]
- negative regulation of extrinsic apoptotic signaling pathway [IBA]
- negative regulation of intrinsic apoptotic signaling pathway [IBA]
- oogenesis [IMP]
- osteoclast development [IGI]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of canonical Wnt signaling pathway [IGI]
- positive regulation of podosome assembly [IDA, IGI]
- progesterone receptor signaling pathway [IBA]
- protein phosphorylation [IDA]
- regulation of cell cycle [IBA]
- regulation of cell projection assembly [IGI]
- regulation of cell proliferation [IBA]
- regulation of intracellular estrogen receptor signaling pathway [IMP]
- regulation of protein binding [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- uterus development [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IBA]
- hormone receptor binding [IBA]
- kinase activity [IMP]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, IMP]
- protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
Mus musculus
PREY
PTPN2
AI325124, Ptpt, TC-PTP
protein tyrosine phosphatase, non-receptor type 2
GO Process (31)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell differentiation [IMP]
- erythrocyte differentiation [IMP]
- glucose homeostasis [IMP]
- insulin receptor signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of chemotaxis [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [IMP]
- negative regulation of interleukin-2-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-4-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-6-mediated signaling pathway [IMP, ISO]
- negative regulation of lipid storage [IMP]
- negative regulation of macrophage colony-stimulating factor signaling pathway [IMP]
- negative regulation of macrophage differentiation [IMP]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of positive thymic T cell selection [IMP]
- negative regulation of prolactin signaling pathway [IMP]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IMP]
- negative regulation of type I interferon-mediated signaling pathway [IMP, ISO]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- negative regulation of tyrosine phosphorylation of Stat6 protein [IMP, ISO]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- positive regulation of gluconeogenesis [IMP]
- protein dephosphorylation [IMP]
- regulation of hepatocyte growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.724 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID