BAIT
TRF
AI266983, Cd176, HP, Tf, Tfn, hpx
transferrin
GO Process (14)
GO Function (3)
GO Component (19)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- SMAD protein signal transduction [IDA]
- actin filament organization [IDA]
- activation of JUN kinase activity [IDA]
- ferric iron transport [ISO]
- iron ion transmembrane transport [ISO]
- iron ion transport [IMP]
- osteoclast differentiation [IDA]
- positive regulation of bone resorption [IDA]
- positive regulation of cell motility [IDA]
- positive regulation of myelination [ISO]
- positive regulation of oligodendrocyte progenitor proliferation [ISO]
- positive regulation of phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical plasma membrane [ISO]
- basal part of cell [ISO]
- basal plasma membrane [ISO]
- basement membrane [ISO]
- blood microparticle [ISO]
- cell surface [ISO]
- coated pit [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [ISO]
- dense body [ISO]
- early endosome [IDA, ISO]
- endocytic vesicle [IDA, ISO]
- endosome [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- late endosome [ISO]
- perinuclear region of cytoplasm [ISO]
- recycling endosome [IDA, ISO]
- vesicle [ISO]
- vesicle coat [ISO]
Mus musculus
PREY
RAB5A
2410015H04Rik, AI663973, AU021172, nnyRab5a
RAB5A, member RAS oncogene family
GO Process (16)
GO Function (6)
GO Component (26)
Gene Ontology Biological Process
- GTP catabolic process [IDA, ISO]
- Rab protein signal transduction [IBA]
- early endosome to late endosome transport [ISO]
- endocytosis [IDA, ISO]
- endosome organization [ISO]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- receptor internalization involved in canonical Wnt signaling pathway [ISO]
- regulation of endocytosis [IBA]
- regulation of endosome size [ISO]
- regulation of filopodium assembly [IBA, ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic vesicle exocytosis [ISO]
- synaptic vesicle recycling [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [ISO]
- axon terminus [ISO]
- cell [IBA]
- cytoplasm [IDA, ISO]
- cytoplasmic side of early endosome membrane [ISO]
- cytosol [ISO]
- dendrite [ISO]
- early endosome [IDA, ISO]
- endocytic vesicle [IDA]
- endosome [IDA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- membrane raft [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- phagocytic vesicle [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- recycling endosome [ISO]
- ruffle [IDA]
- somatodendritic compartment [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- zymogen granule membrane [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.753 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID