BAIT
CDC42
AI747189, AU018915, RP23-246F18.2
cell division cycle 42
GO Process (50)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [ISA]
- Golgi organization [ISO]
- Rho protein signal transduction [TAS]
- actin filament branching [ISO]
- actin filament bundle assembly [IMP]
- actin filament organization [ISO]
- adherens junction organization [IMP]
- canonical Wnt signaling pathway [IMP]
- cardiac conduction system development [IGI]
- cellular protein localization [IMP]
- dendritic cell migration [IGI]
- endosomal transport [TAS]
- epidermis morphogenesis [IMP]
- epithelial cell-cell adhesion [IMP]
- epithelial-mesenchymal cell signaling [IMP]
- establishment of Golgi localization [ISO]
- establishment or maintenance of apical/basal cell polarity [IMP]
- establishment or maintenance of cell polarity [TAS]
- filopodium assembly [IDA]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IMP]
- heart contraction [IGI]
- keratinization [IMP]
- keratinocyte development [IMP]
- multicellular organism growth [IMP]
- negative regulation of gene expression [IMP]
- neuron fate determination [IMP]
- nuclear migration [IMP]
- nucleus localization [IMP]
- organelle transport along microtubule [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of hair follicle cell proliferation [IMP]
- positive regulation of intracellular protein transport [ISO]
- positive regulation of metalloenzyme activity [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of synapse structural plasticity [ISO]
- regulation of mitosis [IMP]
- regulation of protein catabolic process [IMP]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein kinase activity [IMP]
- regulation of protein metabolic process [IMP]
- regulation of protein stability [IMP]
- single organismal cell-cell adhesion [IMP, TAS]
- sprouting angiogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAC1
AL023026, D5Ertd559e
RAS-related C3 botulinum substrate 1
GO Process (51)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IGI]
- GTP catabolic process [IDA, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI]
- actin cytoskeleton organization [ISO]
- actin filament organization [ISO]
- actin filament polymerization [IDA]
- anatomical structure arrangement [IMP]
- auditory receptor cell morphogenesis [IMP]
- axon guidance [IMP]
- bone resorption [ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell motility [ISO]
- cell proliferation [ISO]
- cell-cell junction organization [IMP]
- cellular component movement [ISO]
- cerebral cortex radially oriented cell migration [IMP]
- chemotaxis [ISO]
- cochlea morphogenesis [IMP]
- cytoskeleton organization [IDA]
- dendrite development [IDA]
- dendrite morphogenesis [IGI]
- dopaminergic neuron differentiation [IGI]
- embryonic olfactory bulb interneuron precursor migration [IMP]
- endocytosis [IDA]
- engulfment of apoptotic cell [IDA]
- epithelial cell morphogenesis [IMP]
- hyperosmotic response [IDA]
- lamellipodium assembly [IDA, ISO, TAS]
- localization within membrane [ISO]
- mast cell chemotaxis [ISO]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [IMP, ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [IDA]
- regulation of cell migration [IMP, ISO]
- regulation of respiratory burst [ISO]
- ruffle assembly [IMP]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [ISO]
- small GTPase mediated signal transduction [IDA]
- substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISO]
- actin filament [ISO]
- cell projection [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [IDA]
- focal adhesion [ISO]
- lamellipodium [IDA, ISO]
- membrane [IDA, ISO]
- phagocytic cup [IDA]
- ruffle membrane [IDA]
- trans-Golgi network [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.9035 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID