BAIT
CDKN1B
AA408329, AI843786, Kip1, p27, p27Kip1
cyclin-dependent kinase inhibitor 1B
GO Process (26)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- autophagic cell death [ISO]
- cell cycle arrest [IDA, ISO]
- cell death [ISO]
- cellular response to antibiotic [IDA]
- cellular response to lithium ion [ISO]
- cellular response to organic cyclic compound [IDA]
- inner ear development [IMP]
- mitotic cell cycle arrest [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cellular component movement [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- negative regulation of kinase activity [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of phosphorylation [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of cell death [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of microtubule polymerization [IGI]
- potassium ion transport [IGI]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
RBX1
1500002P15Rik, AA517855, ROC1
ring-box 1
GO Process (5)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.815 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID