BAIT
BID
2700049M22Rik, AI875481, AU022477
BH3 interacting domain death agonist
GO Process (19)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic mitochondrial changes [IDA]
- establishment of protein localization to membrane [ISO]
- extrinsic apoptotic signaling pathway [IMP]
- hepatocyte apoptotic process [IGI]
- mitochondrial outer membrane permeabilization [IGI]
- positive regulation of apoptotic process [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of protein homooligomerization [IDA, ISO]
- positive regulation of protein oligomerization [ISO]
- positive regulation of release of cytochrome c from mitochondria [IGI, ISO]
- protein homooligomerization [IDA]
- protein targeting to mitochondrion [IMP]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- regulation of cell proliferation [IMP]
- regulation of mitochondrial membrane permeability involved in apoptotic process [IGI]
- regulation of protein oligomerization [IDA]
- release of cytochrome c from mitochondria [IDA, IMP, ISO]
- signal transduction in response to DNA damage [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RHOA
Arha, Arha1, Arha2
ras homolog gene family, member A
GO Process (44)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
- GTP catabolic process [IDA, ISO]
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [IDA]
- androgen receptor signaling pathway [IDA]
- apical junction assembly [IDA, ISO]
- apolipoprotein A-I-mediated signaling pathway [ISO]
- cell adhesion [IMP]
- cell differentiation [IDA]
- cell morphogenesis [IGI]
- cell-matrix adhesion [IDA]
- cerebral cortex cell migration [IMP]
- cleavage furrow formation [ISO]
- cytoskeleton organization [IMP]
- forebrain radial glial cell differentiation [IMP]
- integrin-mediated signaling pathway [TAS]
- negative chemotaxis [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of cell death [ISO]
- negative regulation of intracellular steroid hormone receptor signaling pathway [IDA]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron differentiation [ISO]
- ossification involved in bone maturation [IMP]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of podosome assembly [IGI]
- positive regulation of smooth muscle contraction [ISO]
- positive regulation of stress fiber assembly [ISO]
- regulation of calcium ion transport [ISO]
- regulation of cell migration [ISO]
- regulation of dendrite development [ISO]
- regulation of neural precursor cell proliferation [IMP]
- regulation of neuron projection development [IDA]
- regulation of osteoblast proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to drug [ISO]
- skeletal muscle tissue development [IDA]
- spindle assembly involved in mitosis [ISO]
- stress fiber assembly [IDA]
- stress-activated protein kinase signaling cascade [ISO]
- trabecula morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7895 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID