BAIT
HSPA9
74kDa, Csa, Grp75, Hsc74, Hsp74, Hsp74a, Hspa9a, Mortalin, Mot-2, Mot2, Mthsp70, Pbp74
heat shock protein 9
GO Process (1)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SIRT3
2310003L23Rik, AI848213, Sir2l3
sirtuin 3
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- aerobic respiration [ISO]
- histone H3 deacetylation [IDA]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of peptidyl-lysine acetylation [IDA, IMP]
- negative regulation of reactive oxygen species metabolic process [ISO]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of insulin secretion [ISO]
- protein deacetylation [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.727 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID