BAIT
WNK1
6430573H23Rik, EG406236, Hsn2, Prkwnk1, mKIAA0344
WNK lysine deficient protein kinase 1
GO Process (10)
GO Function (10)
GO Component (1)
Gene Ontology Biological Process
- intracellular signal transduction [ISO]
- ion transport [IDA]
- negative regulation of kinase activity [ISO]
- negative regulation of pancreatic juice secretion [IMP]
- negative regulation of phosphatase activity [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of systemic arterial blood pressure [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of cellular process [IDA]
Gene Ontology Molecular Function- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
- ATP binding [ISO]
- chloride channel inhibitor activity [ISO]
- magnesium ion binding [ISO]
- phosphatase binding [ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein serine/threonine kinase inhibitor activity [ISO]
Mus musculus
PREY
SLC9A1
AW554487, Apnh, Nhe1, swe, RP23-32C12.6
solute carrier family 9 (sodium/hydrogen exchanger), member 1
GO Process (33)
GO Function (3)
GO Component (18)
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IMP]
- cellular response to acidic pH [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to hypoxia [ISO]
- cellular response to insulin stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- embryo development [IMP]
- hydrogen ion transmembrane transport [IMP, ISO]
- negative regulation of apoptotic process [ISO]
- neuron death [ISO]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of action potential [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of calcineurin-NFAT signaling cascade [ISO]
- positive regulation of calcium:sodium antiporter activity [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of mitochondrial membrane permeability [ISO]
- positive regulation of the force of heart contraction [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of cardiac muscle contraction by calcium ion signaling [ISO]
- regulation of intracellular pH [ISO]
- regulation of pH [IDA, IMP, ISO]
- regulation of sensory perception of pain [ISO]
- regulation of the force of heart contraction [ISO]
- regulation of the force of heart contraction by cardiac conduction [ISO]
- response to acidic pH [IMP, ISO]
- response to muscle stretch [ISO]
- response to organic cyclic compound [ISO]
- sodium ion import across plasma membrane [ISO]
- sodium ion transmembrane transport [IMP]
- sodium ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [ISO, TAS]
- cation-transporting ATPase complex [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of plasma membrane [ISO]
- intercalated disc [ISO]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrion [ISO]
- nucleoplasm [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7995 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID