BAIT
BAG4
2410112I15Rik, SODD
BCL2-associated athanogene 4
GO Process (13)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to tumor necrosis factor [ISO]
- negative regulation of mRNA modification [ISO]
- negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [IDA]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of fibroblast migration [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of stress fiber assembly [IMP]
- protein heterooligomerization [ISO]
- protein localization to plasma membrane [IDA]
- ruffle assembly [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
STUB1
0610033N24Rik, 2210017D18Rik, 2310040B03Rik, AW046544, Chip
STIP1 homology and U-Box containing protein 1
GO Process (15)
GO Function (16)
GO Component (9)
Gene Ontology Biological Process
- cellular response to misfolded protein [IMP, ISO]
- misfolded or incompletely synthesized protein catabolic process [IMP, ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of protein ubiquitination [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein folding [TAS]
- protein maturation [TAS]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [TAS]
- regulation of glucocorticoid metabolic process [ISO, ISS]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7595 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID