MAPT
Gene Ontology Biological Process
- adult walking behavior [IGI]
- apoptotic process [ISO]
- axon cargo transport [IGI]
- axon extension [IMP]
- axonogenesis [IGI]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- microtubule cytoskeleton organization [IMP, ISO]
- mitochondrion transport along microtubule [IMP]
- negative regulation of intracellular transport [IMP]
- neuron migration [IMP]
- positive regulation of axon extension [IMP, ISO]
- positive regulation of microtubule polymerization [ISO]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [IDA]
- response to nutrient [ISO]
- response to organic substance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA, ISO]
- axonal growth cone [ISO]
- axoneme [IDA]
- cell [IGI]
- cytoplasm [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO]
- intracellular [IGI]
- microtubule cytoskeleton [IDA]
- neuron projection [ISO]
- nuclear periphery [ISO]
- nucleus [IDA]
- plasma membrane [ISO]
- postsynaptic density [IDA]
- tubulin complex [ISO]
STUB1
Gene Ontology Biological Process
- cellular response to misfolded protein [IMP, ISO]
- misfolded or incompletely synthesized protein catabolic process [IMP, ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of protein ubiquitination [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein folding [TAS]
- protein maturation [TAS]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [TAS]
- regulation of glucocorticoid metabolic process [ISO, ISS]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.8795 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STUB1 MAPT | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID