STXBP1
Gene Ontology Biological Process
- axon target recognition [IMP]
- exocytosis [IMP]
- long term synaptic depression [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of synaptic transmission, GABAergic [IDA]
- neuromuscular synaptic transmission [IMP]
- neurotransmitter secretion [IMP]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of exocytosis [ISO]
- protein localization to plasma membrane [ISO]
- protein stabilization [ISO]
- regulation of synaptic vesicle priming [ISO]
- synaptic vesicle maturation [IMP]
- vesicle docking involved in exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STX1A
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [IMP]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of exocytosis [ISO]
- response to gravity [ISO]
- secretion by cell [ISO]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- actomyosin [ISO]
- cell [IMP]
- endomembrane system [IBA]
- integral component of membrane [IBA]
- intracellular [IBA]
- intracellular organelle [ISO]
- membrane [IDA]
- neuron projection [IDA, ISO]
- plasma membrane [IDA, ISO, TAS]
- protein complex [ISO]
- secretory granule [ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [ISO]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.8315 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX1A STXBP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| STX1A STXBP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| STXBP1 STX1A | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.8009 | BioGRID | 3499968 |
Curated By
- BioGRID