BAIT
PTPRZ1
AI850339, DSD-1-PG, PTPbeta, PTPzeta, Ptprz, Ptpz, RPTPz, Rptpbeta
protein tyrosine phosphatase, receptor type Z, polypeptide 1
GO Process (20)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- axonal fasciculation [ISO]
- axonogenesis [IDA]
- hematopoietic progenitor cell differentiation [IMP]
- learning or memory [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of dendrite development [ISO]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- positive regulation of Schwann cell migration [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of dendrite development [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of neuron migration [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- protein dephosphorylation [ISO]
- regulation of dendrite morphogenesis [ISO]
- regulation of oligodendrocyte progenitor proliferation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TNR
J1-tenascin, TN-R, janusin, restrictin
tenascin R
GO Process (17)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- associative learning [IMP]
- extracellular matrix organization [IMP]
- locomotory exploration behavior [IMP]
- long-term synaptic potentiation [IMP]
- negative regulation of axon extension [IDA]
- negative regulation of axon extension involved in regeneration [IMP]
- negative regulation of cell adhesion [ISO]
- negative regulation of cell-cell adhesion [IDA, IMP]
- negative regulation of neuron projection development [IDA]
- negative regulation of synaptic transmission [IMP]
- neuromuscular process controlling balance [IMP]
- neuron cell-cell adhesion [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- positive regulation of transmission of nerve impulse [IMP]
- regulation of synaptic transmission [IMP]
- synapse organization [IMP]
- telencephalon cell migration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.8 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID