BAIT
BMPR2
2610024H22Rik, AL117858, AW546137, BB189135, BMP-2, BMPR-2, BMPR-II, BMPRII, BRK-3, Gm20272
bone morphogenetic protein receptor, type II (serine/threonine kinase)
GO Process (33)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- anterior/posterior pattern specification [IGI, IMP]
- artery development [IMP]
- blood vessel remodeling [IMP]
- chondrocyte development [ISO]
- limb development [IGI]
- lung alveolus development [IMP]
- lymphangiogenesis [IMP]
- lymphatic endothelial cell differentiation [IMP]
- maternal placenta development [IMP]
- mesoderm formation [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of chondrocyte proliferation [ISO]
- negative regulation of systemic arterial blood pressure [ISO]
- negative regulation of vasoconstriction [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of bone mineralization [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of cell proliferation [ISO]
- regulation of lung blood pressure [IMP, ISO]
- retina vasculature development in camera-type eye [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP]
- venous blood vessel development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TUBB4A
AI325297, M(beta)4, Tubb, Tubb4
tubulin, beta 4A class IVA
GO Process (0)
GO Function (0)
GO Component (9)
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7985 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID