BAIT
EIF4A3
2400003O03Rik, Ddx48, eIF4A-III, mKIAA0111, RP23-13O17.1
eukaryotic translation initiation factor 4A3
GO Process (7)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- embryonic cranial skeleton morphogenesis [ISO]
- negative regulation of translation [ISO]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [ISO]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of translation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WDR77
2610003I18Rik, 2610312E17Rik, C79984, p44/MEP50
WD repeat domain 77
GO Process (6)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of cell proliferation [IGI]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of cell proliferation [IGI]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.7375 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID