BAIT
LIN7C
9130007B12Rik, AI303698, AU019331, AW125731, D2Ertd520e, LIN-7-C, LIN-7C, MALS-3, Veli3, RP23-207C2.1
lin-7 homolog C (C. elegans)
GO Process (2)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WFS1
AI481085, wolframin
Wolfram syndrome 1 homolog (human)
GO Process (24)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- calcium ion homeostasis [ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- endoplasmic reticulum unfolded protein response [IDA, IMP]
- glucose homeostasis [ISO]
- kidney development [ISO]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of programmed cell death [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of type B pancreatic cell apoptotic process [IMP, ISO]
- neurological system process [ISO]
- polyubiquitinated misfolded protein transport [IDA]
- positive regulation of calcium ion transport [ISO]
- positive regulation of growth [IMP]
- positive regulation of protein metabolic process [ISO]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of proteolysis [IDA]
- protein stabilization [IMP]
- regulation of cell cycle [NAS]
- renal water homeostasis [ISO]
- response to endoplasmic reticulum stress [IDA, ISO]
- sensory perception of sound [ISO]
- visual perception [ISO, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.8055 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID