BAIT
ADAM8
CD156, CD156a, E430039A18Rik, MS2
a disintegrin and metallopeptidase domain 8
GO Process (33)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- activation of MAPK activity involved in innate immune response [IDA]
- angiogenesis [IDA]
- blood vessel endothelial cell migration [NAS]
- cell morphogenesis [IMP]
- cell-matrix adhesion [TAS]
- cellular response to hypoxia [ISO]
- inflammatory response [ISO]
- leukocyte migration involved in inflammatory response [IMP]
- lymphocyte chemotaxis [IDA]
- membrane fusion [TAS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of thymocyte aggregation [NAS]
- osteoclast fusion [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell differentiation in thymus [IDA]
- positive regulation of T cell migration [IMP]
- positive regulation of acute inflammatory response [IMP]
- positive regulation of bone resorption [IDA, IMP]
- positive regulation of cell adhesion [IDA]
- positive regulation of cellular extravasation [IMP]
- positive regulation of eosinophil migration [IMP]
- positive regulation of fibronectin-dependent thymocyte migration [IMP]
- positive regulation of inflammatory response [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA, ISO]
- positive regulation of neutrophil extravasation [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of thymocyte apoptotic process [IMP]
- positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [IMP]
- proteolysis [ISO]
- regulation of cell-cell adhesion [ISO]
- regulation of osteoclast differentiation [NAS]
- single organismal cell-cell adhesion [IDA]
- tissue morphogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alpha9-beta1 integrin-ADAM8 complex [IDA]
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dense core granule membrane [ISO]
- integral component of plasma membrane [ISO]
- phagolysosome [ISO]
- plasma membrane [IDA, ISO]
- podosome [ISO, TAS]
- specific granule [ISO]
- tertiary granule [ISO]
Mus musculus
PREY
ADAM23
AW046396, MDC3, DN-74E14.1
a disintegrin and metallopeptidase domain 23
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.765 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID