BAIT
EIF2AK2
2310047A08Rik, 4732414G15Rik, AI467567, AI747578, Pkr, Prkr, Tik
eukaryotic translation initiation factor 2-alpha kinase 2
GO Process (24)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- endoplasmic reticulum unfolded protein response [IDA]
- negative regulation of apoptotic process [IGI]
- negative regulation of osteoblast proliferation [ISO]
- negative regulation of translation [ISO]
- negative regulation of viral genome replication [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of NIK/NF-kappaB signaling [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of chemokine production [IMP]
- positive regulation of cytokine production [IMP]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of NLRP3 inflammasome complex assembly [IMP]
- regulation of hematopoietic progenitor cell differentiation [IMP]
- regulation of hematopoietic stem cell differentiation [IMP]
- regulation of hematopoietic stem cell proliferation [IMP]
- response to interferon-alpha [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [ISO]
- response to virus [ISO]
- response to vitamin E [ISO]
- translation [IDA]
Gene Ontology Molecular Function
Mus musculus
PREY
ADAR
AV242451, Adar1, Adar1p110, Adar1p150, mZaADAR
adenosine deaminase, RNA-specific
GO Process (23)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- adenosine to inosine editing [IDA, IMP, ISO]
- base conversion or substitution editing [ISO]
- defense response to virus [IMP]
- definitive hemopoiesis [IMP]
- erythrocyte differentiation [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- hematopoietic stem cell homeostasis [IMP]
- in utero embryonic development [IMP]
- miRNA loading onto RISC involved in gene silencing by miRNA [ISO]
- negative regulation of RNA interference [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IMP, ISO]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- negative regulation of viral genome replication [IMP]
- osteoblast differentiation [IMP]
- positive regulation of viral genome replication [IMP, ISO]
- pre-miRNA processing [ISO]
- production of miRNAs involved in gene silencing by miRNA [IMP]
- protein export from nucleus [ISO]
- protein import into nucleus [ISO]
- response to interferon-alpha [ISO]
- response to virus [ISO]
- somatic diversification of immune receptors via somatic mutation [IDA]
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.828 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID