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BAIT

APOB

AI315052, Apo B-100, apob-100, apob-48, mCG_129875

apolipoprotein B

GO Process (26)

GO Function (6)

GO Component (15)

Gene Ontology Biological Process

artery morphogenesis [IGI]

cholesterol efflux [IGI]

cholesterol homeostasis [IGI, IMP, ISO]

cholesterol metabolic process [ISO]

cholesterol transport [IMP, ISO]

fertilization [IMP]

in utero embryonic development [IMP]

lipid catabolic process [IMP]

lipid metabolic process [IDA, IGI, IMP, ISO]

lipoprotein biosynthetic process [IGI]

lipoprotein catabolic process [IGI]

lipoprotein metabolic process [IGI, IMP]

lipoprotein transport [IGI, IMP]

low-density lipoprotein particle clearance [ISO]

low-density lipoprotein particle remodeling [ISO]

nervous system development [IMP]

positive regulation of cholesterol storage [ISO]

positive regulation of lipid storage [ISO]

positive regulation of macrophage derived foam cell differentiation [ISO]

post-embryonic development [IMP]

regulation of cholesterol biosynthetic process [IMP]

response to carbohydrate [ISO]

sperm motility [IMP]

spermatogenesis [IMP]

triglyceride catabolic process [IMP, ISO]

triglyceride mobilization [IMP]

Gene Ontology Molecular Function

cholesterol transporter activity [ISO]
heparin binding [ISO]
lipase binding [ISO]
lipid binding [ISO]
low-density lipoprotein particle receptor binding [ISO]
phospholipid binding [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

APOA4

Apoa-4

apolipoprotein A-IV

GO Process (28)

GO Function (8)

GO Component (7)

Gene Ontology Biological Process

cholesterol biosynthetic process [IBA]

cholesterol efflux [IBA, ISO]

cholesterol homeostasis [IBA, ISO]

cholesterol metabolic process [ISO]

high-density lipoprotein particle assembly [IBA]

hydrogen peroxide catabolic process [ISO]

innate immune response in mucosa [IMP, ISO]

leukocyte cell-cell adhesion [ISO]

lipid homeostasis [ISO]

lipid transport [ISO]

lipoprotein metabolic process [IBA]

multicellular organismal lipid catabolic process [ISO]

negative regulation of plasma lipoprotein particle oxidation [ISO]

neuron projection regeneration [IBA]

phosphatidylcholine metabolic process [IBA, ISO]

phospholipid efflux [IBA, ISO]

positive regulation of cholesterol esterification [IBA, ISO]

positive regulation of fatty acid biosynthetic process [IBA, ISO]

positive regulation of lipoprotein lipase activity [IBA, ISO]

positive regulation of triglyceride catabolic process [IBA, ISO]

protein-lipid complex assembly [ISO]

regulation of cholesterol transport [ISO]

regulation of intestinal cholesterol absorption [IMP]

removal of superoxide radicals [ISO]

response to lipid hydroperoxide [ISO]

reverse cholesterol transport [IBA, ISO]

triglyceride homeostasis [IBA]

very-low-density lipoprotein particle remodeling [IBA, ISO]

Gene Ontology Molecular Function

antioxidant activity [ISO]
cholesterol binding [IBA]
cholesterol transporter activity [IBA, ISO]
copper ion binding [ISO]
lipid binding [ISO]
phosphatidylcholine binding [IBA, ISO]
phosphatidylcholine-sterol O-acyltransferase activator activity [IBA, ISO]
protein homodimerization activity [ISO]

Gene Ontology Cellular Component

blood microparticle [IBA, ISO]

cell surface [ISO]

chylomicron [IBA, ISO]

extracellular space [IDA, ISO]

extracellular vesicular exosome [ISO]

high-density lipoprotein particle [IBA, ISO]

very-low-density lipoprotein particle [ISO]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.

Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Abdullatif AA, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, Emili A

Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]

Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]

Quantitative Score

0.87 [EPIC Score]

Throughput

High Throughput

Additional Notes

High confidence interactions had an EPIC Score >= 0.683

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
APOB APOA4	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Callow MJ (1995)	Low	-	BioGRID	-

Curated By

BioGRID