BAIT
PTPRF
AA591035, LAR, LARS, RPTP-LAR, RP23-94L18.2
protein tyrosine phosphatase, receptor type, F
GO Process (20)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- cell migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytokine-mediated signaling pathway [ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of neurotrophin TRK receptor signaling pathway [ISO]
- negative regulation of receptor binding [ISO]
- nervous system development [ISO]
- neuron projection regeneration [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- protein dephosphorylation [ISO]
- regulation of axon regeneration [IMP]
- regulation of neuron projection development [IMP]
- regulation of synapse structure or activity [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
APOB
AI315052, Apo B-100, apob-100, apob-48, mCG_129875
apolipoprotein B
GO Process (26)
GO Function (6)
GO Component (15)
Gene Ontology Biological Process
- artery morphogenesis [IGI]
- cholesterol efflux [IGI]
- cholesterol homeostasis [IGI, IMP, ISO]
- cholesterol metabolic process [ISO]
- cholesterol transport [IMP, ISO]
- fertilization [IMP]
- in utero embryonic development [IMP]
- lipid catabolic process [IMP]
- lipid metabolic process [IDA, IGI, IMP, ISO]
- lipoprotein biosynthetic process [IGI]
- lipoprotein catabolic process [IGI]
- lipoprotein metabolic process [IGI, IMP]
- lipoprotein transport [IGI, IMP]
- low-density lipoprotein particle clearance [ISO]
- low-density lipoprotein particle remodeling [ISO]
- nervous system development [IMP]
- positive regulation of cholesterol storage [ISO]
- positive regulation of lipid storage [ISO]
- positive regulation of macrophage derived foam cell differentiation [ISO]
- post-embryonic development [IMP]
- regulation of cholesterol biosynthetic process [IMP]
- response to carbohydrate [ISO]
- sperm motility [IMP]
- spermatogenesis [IMP]
- triglyceride catabolic process [IMP, ISO]
- triglyceride mobilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- actin cytoskeleton [ISO]
- chylomicron [ISO]
- cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- intermediate-density lipoprotein particle [ISO]
- intracellular membrane-bounded organelle [ISO]
- low-density lipoprotein particle [ISO]
- mature chylomicron [ISO]
- plasma membrane [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle lumen [ISO]
- vesicle membrane [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.849 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID