BAIT
SRGAP1
4930572H05Rik, Arhgap13
SLIT-ROBO Rho GTPase activating protein 1
GO Process (5)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ARHGEF7
Cool, PIX, Pak3bp, betaPix, betaPix-b, betaPix-c, cool-1, mKIAA0142, p85Cool1, p85SPR
Rho guanine nucleotide exchange factor (GEF7)
GO Process (11)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- astrocyte cell migration [ISO]
- focal adhesion assembly [ISO]
- hematopoietic progenitor cell differentiation [IGI]
- lamellipodium assembly [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rac GTPase activity [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of lamellipodium morphogenesis [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- small GTPase mediated signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.86 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID