BAIT
RB1
Rb, Rb-1, pRb
retinoblastoma 1
GO Process (36)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- cell cycle arrest [IMP]
- cell division [IMP]
- cell morphogenesis involved in neuron differentiation [IMP]
- digestive tract development [IMP]
- enucleate erythrocyte differentiation [IGI]
- glial cell apoptotic process [IMP]
- hepatocyte apoptotic process [IMP, ISO]
- maintenance of mitotic sister chromatid cohesion [ISO]
- myoblast differentiation [ISO]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle [IMP]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron apoptotic process [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron projection development [IMP]
- positive regulation of macrophage differentiation [IGI]
- positive regulation of mitotic metaphase/anaphase transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- protein localization to chromosome, centromeric region [ISO]
- regulation of cell cycle [IMP]
- regulation of cohesin localization to chromatin [ISO]
- regulation of lipid kinase activity [ISO]
- regulation of mitotic cell cycle [ISO]
- sister chromatid biorientation [ISO]
- skeletal muscle cell differentiation [IMP]
- striated muscle cell differentiation [IGI]
Gene Ontology Molecular Function
Mus musculus
PREY
ARNT
D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, bHLHe2, mKIAA4051
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell differentiation [IMP]
- embryonic placenta development [IMP]
- intracellular receptor signaling pathway [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [TAS]
- response to hypoxia [IDA, ISO]
- response to toxic substance [TAS]
Gene Ontology Molecular Function- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.905 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID