BAIT
BLM
Bloom syndrome, RecQ helicase-like
GO Process (24)
GO Function (13)
GO Component (11)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- DNA double-strand break processing [ISO]
- DNA duplex unwinding [IDA, ISO]
- DNA repair [IDA]
- DNA strand renaturation [ISO]
- alpha-beta T cell differentiation [IMP]
- cellular response to DNA damage stimulus [ISO]
- cellular response to camptothecin [ISO]
- cellular response to hydroxyurea [ISO]
- cellular response to ionizing radiation [ISO]
- chromosome organization [IMP]
- mitotic G2 DNA damage checkpoint [ISO]
- negative regulation of DNA recombination [ISO]
- negative regulation of cell division [ISO]
- negative regulation of mitotic recombination [IMP]
- negative regulation of thymocyte apoptotic process [IGI, IMP]
- positive regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- protein oligomerization [ISO]
- regulation of binding [IDA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- replication fork processing [ISO]
- response to X-ray [ISO]
- telomere maintenance [IGI]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATP-dependent 3'-5' DNA helicase activity [IDA]
- ATP-dependent DNA helicase activity [ISO]
- ATP-dependent helicase activity [ISO]
- ATPase activity [ISO]
- G-quadruplex DNA binding [ISO]
- annealing helicase activity [ISO]
- bubble DNA binding [ISO]
- four-way junction helicase activity [ISO]
- helicase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- single-stranded DNA binding [ISO]
- ATP binding [ISO]
- ATP-dependent 3'-5' DNA helicase activity [IDA]
- ATP-dependent DNA helicase activity [ISO]
- ATP-dependent helicase activity [ISO]
- ATPase activity [ISO]
- G-quadruplex DNA binding [ISO]
- annealing helicase activity [ISO]
- bubble DNA binding [ISO]
- four-way junction helicase activity [ISO]
- helicase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- single-stranded DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
ATM
AI256621, C030026E19Rik
ataxia telangiectasia mutated
GO Process (35)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- DNA damage induced protein phosphorylation [ISO]
- DNA repair [IDA, IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cell cycle arrest [ISO]
- cellular response to DNA damage stimulus [ISO, TAS]
- cellular response to gamma radiation [ISO]
- double-strand break repair via homologous recombination [IBA]
- female gamete generation [IMP]
- heart development [IGI]
- histone mRNA catabolic process [ISO]
- histone phosphorylation [ISO]
- histone-serine phosphorylation [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- lipoprotein catabolic process [IGI]
- mitotic spindle assembly checkpoint [ISO]
- negative regulation of B cell proliferation [ISO]
- neuron apoptotic process [IGI]
- oocyte development [IMP]
- peptidyl-serine phosphorylation [ISO]
- phosphatidylinositol phosphorylation [ISO]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [IGI]
- pre-B cell allelic exclusion [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of cell cycle [ISO]
- replicative senescence [ISO]
- response to hypoxia [ISO]
- response to ionizing radiation [IGI, ISO]
- signal transduction involved in mitotic G2 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [ISO]
- DNA-dependent protein kinase activity [ISO]
- histone serine kinase activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IBA, ISO]
- protein kinase activity [IDA, TAS]
- protein serine/threonine kinase activity [ISO]
- 1-phosphatidylinositol-3-kinase activity [ISO]
- DNA-dependent protein kinase activity [ISO]
- histone serine kinase activity [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [IBA, ISO]
- protein kinase activity [IDA, TAS]
- protein serine/threonine kinase activity [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.941 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID