BAIT
DNAJB5
1110058L06Rik, AI462558, Hsc40, Hsp40-3, RP23-124L1.3
DnaJ (Hsp40) homolog, subfamily B, member 5
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
CACNA1A
APCA, BI, Caca1a, Cacnl1a4, Cav2.1, Ccha1a, EA2, FHM, HPCA, MHP, MHP1, SCA6, alpha1A, la, nmf352, rkr, tg
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (50)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- adult walking behavior [IGI, IMP]
- behavioral response to pain [IMP]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IGI]
- calcium ion transport [IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- calcium ion-dependent exocytosis of neurotransmitter [IMP]
- cell death [ISO]
- cell growth [IMP]
- cellular chloride ion homeostasis [IMP]
- central nervous system neuron differentiation [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebellar molecular layer development [IMP]
- cerebellum maturation [IMP]
- dendrite morphogenesis [IMP]
- gamma-aminobutyric acid secretion [IMP]
- gamma-aminobutyric acid signaling pathway [IMP]
- glucose metabolic process [IMP]
- hormone metabolic process [IMP]
- membrane depolarization [IMP]
- membrane depolarization during action potential [IBA]
- musculoskeletal movement, spinal reflex action [IMP]
- negative regulation of hormone biosynthetic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neurological system process [IMP]
- neuromuscular process [IGI, IMP]
- neuromuscular process controlling balance [IMP]
- neuromuscular synaptic transmission [IMP]
- neuron-neuron synaptic transmission [IMP]
- neurotransmitter metabolic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- receptor clustering [IMP]
- regulation of acetylcholine secretion, neurotransmission [IMP]
- regulation of axonogenesis [IMP]
- regulation of calcium ion-dependent exocytosis [IDA]
- regulation of ion transmembrane transport [IGI]
- regulation of membrane potential [IMP]
- response to pain [IMP]
- rhythmic synaptic transmission [IMP]
- sensory perception of pain [ISO]
- spinal cord motor neuron differentiation [IMP]
- sulfur amino acid metabolic process [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP, ISO]
- synaptic transmission, GABAergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- thyroid hormone metabolic process [IMP]
- transmission of nerve impulse [IMP]
- vestibular nucleus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.904 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID