BAIT
CACNA1C
Cav1.2, Cchl1a1, D930026N18Rik, MBC, MELC-CC
calcium channel, voltage-dependent, L type, alpha 1C subunit
GO Process (19)
GO Function (9)
GO Component (16)
Gene Ontology Biological Process
- adult walking behavior [IGI]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IDA, IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- cellular calcium ion homeostasis [IMP]
- glucose homeostasis [IMP]
- growth hormone secretion [IDA]
- insulin secretion [IMP]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- regulation of blood pressure [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of organ growth [IMP]
- regulation of vasoconstriction [IMP]
- smooth muscle contraction [IMP]
- smooth muscle contraction involved in micturition [IMP]
- synaptic transmission [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [IPI]
- high voltage-gated calcium channel activity [IBA, ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase 2A binding [ISO]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [IPI]
- high voltage-gated calcium channel activity [IBA, ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase 2A binding [ISO]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
Gene Ontology Cellular Component
- T-tubule [IDA, ISO, TAS]
- Z disc [IDA, ISO]
- caveolar macromolecular signaling complex [IDA]
- cell [IMP]
- cytoplasm [ISO]
- cytosol [ISO]
- dendrite [ISO]
- dendritic shaft [IDA]
- integral component of membrane [ISO]
- membrane [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
- sarcolemma [ISO]
- voltage-gated calcium channel complex [ISO, TAS]
Mus musculus
PREY
CACNB4
3110038O15Rik, Cchb4, lh, RP23-435G20.4
calcium channel, voltage-dependent, beta 4 subunit
GO Process (22)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- Peyer's patch development [IMP]
- T cell differentiation [IMP]
- T cell receptor signaling pathway [IMP]
- adult walking behavior [IMP]
- cAMP metabolic process [IMP]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IMP, ISO]
- cellular calcium ion homeostasis [IMP]
- detection of light stimulus involved in visual perception [IMP]
- gamma-aminobutyric acid secretion [IMP]
- gamma-aminobutyric acid signaling pathway [IMP]
- muscle fiber development [IMP]
- neurological system process [IMP]
- neuromuscular junction development [IMP]
- neuronal action potential propagation [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [IMP]
- regulation of voltage-gated calcium channel activity [IBA, ISO]
- spleen development [IMP]
- synaptic transmission, GABAergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.734 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID