BAIT
CRY1
AU020726, AU021000, Phll1
cryptochrome 1 (photolyase-like)
GO Process (18)
GO Function (12)
GO Component (2)
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [IDA]
- circadian regulation of gene expression [IGI, IMP]
- circadian rhythm [IDA, IMP]
- entrainment of circadian clock by photoperiod [IMP]
- gluconeogenesis [IMP]
- glucose homeostasis [IGI]
- lipid storage [IGI]
- negative regulation of G-protein coupled receptor protein signaling pathway [IMP]
- negative regulation of circadian rhythm [IDA, IMP]
- negative regulation of glucocorticoid receptor signaling pathway [IDA, IGI]
- negative regulation of glucocorticoid secretion [IGI]
- negative regulation of protein ubiquitination [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, IGI, ISO]
- regulation of DNA damage checkpoint [IDA]
- regulation of circadian rhythm [IMP]
- response to glucagon [IMP]
- response to insulin [IGI]
Gene Ontology Molecular Function- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA, ISO]
- histone deacetylase binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin binding [IDA]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA, ISO]
- histone deacetylase binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
CBLB
AI429560, AI851073, Cbl-b
Casitas B-lineage lymphoma b
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- T cell activation [IMP]
- immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.859 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID