BAIT
SOS1
4430401P03Rik, 9630010N06, AI449023
son of sevenless homolog 1 (Drosophila)
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- B cell homeostasis [IGI]
- Ras protein signal transduction [ISO]
- fibroblast growth factor receptor signaling pathway [IGI]
- lymphocyte homeostasis [IGI]
- neurotrophin TRK receptor signaling pathway [ISO]
- positive regulation of Ras GTPase activity [IMP, ISO]
- positive regulation of small GTPase mediated signal transduction [ISO]
- regulation of T cell differentiation in thymus [IGI]
- regulation of T cell proliferation [IGI]
- regulation of pro-B cell differentiation [IGI]
- small GTPase mediated signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CD2AP
AL024079, C78928, METS-1, Mets1
CD2-associated protein
GO Process (8)
GO Function (7)
GO Component (12)
Gene Ontology Biological Process
- cell migration [ISO]
- negative regulation of transforming growth factor beta1 production [IGI]
- positive regulation of protein localization to nucleus [IGI]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- regulation of actin cytoskeleton reorganization [IGI]
- regulation of receptor-mediated endocytosis [ISO]
- single organismal cell-cell adhesion [ISO]
- vesicle organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.928 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID