BAIT
VPS4B
8030489C12Rik, Skd1
vacuolar protein sorting 4b (yeast)
GO Process (16)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cholesterol transport [IMP]
- endosomal transport [ISO]
- endosome organization [IMP]
- endosome to lysosome transport via multivesicular body sorting pathway [ISO]
- intracellular cholesterol transport [ISO]
- negative regulation of exosomal secretion [ISO]
- positive regulation of exosomal secretion [ISO]
- positive regulation of viral release from host cell [ISO]
- potassium ion transport [IDA]
- regulation of viral process [ISO]
- response to lipid [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [ISO]
- vacuole organization [IBA]
- viral budding via host ESCRT complex [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CHMP4B
2010012F05Rik, C76846, Snf7-2, RP23-29D15.3
charged multivesicular body protein 4B
GO Process (8)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of autophagic vacuole assembly [ISO]
- negative regulation of neuron death [ISO]
- positive regulation of viral release from host cell [ISO]
- posttranslational protein targeting to membrane [ISO]
- protein homooligomerization [ISO]
- regulation of viral process [ISO]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [ISO]
- viral budding via host ESCRT complex [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.834 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID