BAIT
NALCN
A530023G15Rik, AI849508, Vgcnl1
sodium leak channel, non-selective
GO Process (4)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CHRM3
Chrm-3, M3, M3R
cholinergic receptor, muscarinic 3, cardiac
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISO, TAS]
- digestion [IMP]
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway [TAS]
- positive regulation of smooth muscle contraction [IDA, ISO]
- regulation of vascular smooth muscle contraction [ISO]
- regulation of vasoconstriction [ISO]
- smooth muscle contraction [IMP]
- synaptic transmission [ISO]
- synaptic transmission, cholinergic [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.97 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID