BAIT
TOPAZ1
Gm9524
testis and ovary specific PAZ domain containing 1
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
DACT1
4921528D17Rik, AI115603, DAPPER, DAPPER1, FRODO, Frd1, Frodo1, MDpr1, MTNG3, THYEX3
dapper homolog 1, antagonist of beta-catenin (xenopus)
GO Process (19)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IMP]
- dendrite morphogenesis [IGI, IMP]
- embryonic hindgut morphogenesis [IMP]
- embryonic morphogenesis [IMP]
- gastrulation with mouth forming second [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of JNK cascade [IDA, ISO]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of protein catabolic process [ISO]
- regulation of Wnt signaling pathway, planar cell polarity pathway [IGI, IMP]
- regulation of catenin import into nucleus [ISO]
- regulation of nodal signaling pathway [IDA]
- regulation of protein stability [ISO]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.942 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID