BAIT
PKD2
C030034P18Rik, PC2, TRPP2
polycystic kidney disease 2
GO Process (37)
GO Function (21)
GO Component (21)
Gene Ontology Biological Process
- JAK-STAT cascade [IDA]
- calcium ion transmembrane transport [IDA, ISO]
- calcium ion transport [IMP, ISO]
- cell cycle arrest [IDA]
- cellular calcium ion homeostasis [IMP]
- cellular response to fluid shear stress [IMP, ISO]
- cellular response to hydrostatic pressure [ISO]
- cellular response to osmotic stress [ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- detection of mechanical stimulus [IMP]
- detection of nodal flow [IMP]
- determination of left/right symmetry [IMP]
- determination of liver left/right asymmetry [ISO]
- embryonic placenta development [IMP]
- heart development [IMP]
- heart looping [ISO]
- kidney development [IGI, IMP]
- liver development [IGI]
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- placenta blood vessel development [IMP]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISO]
- positive regulation of nitric oxide biosynthetic process [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- potassium ion transmembrane transport [IDA]
- regulation of cAMP metabolic process [IMP]
- regulation of calcium ion import [ISO]
- regulation of cell proliferation [ISO]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- renal system development [IGI]
- renal tubule morphogenesis [IMP]
- sodium ion transmembrane transport [ISO]
- transmembrane transport [IMP]
Gene Ontology Molecular Function- ATPase binding [IPI]
- HLH domain binding [ISO]
- actinin binding [ISO]
- alpha-actinin binding [ISO]
- calcium channel activity [IDA, TAS]
- calcium ion binding [IDA]
- calcium-induced calcium release activity [ISO]
- channel activity [IMP]
- cytoskeletal protein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- muscle alpha-actinin binding [ISO]
- phosphoprotein binding [ISO]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated calcium channel activity [ISO]
- voltage-gated cation channel activity [ISO]
- voltage-gated ion channel activity [ISO]
- voltage-gated sodium channel activity [ISO]
- ATPase binding [IPI]
- HLH domain binding [ISO]
- actinin binding [ISO]
- alpha-actinin binding [ISO]
- calcium channel activity [IDA, TAS]
- calcium ion binding [IDA]
- calcium-induced calcium release activity [ISO]
- channel activity [IMP]
- cytoskeletal protein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- muscle alpha-actinin binding [ISO]
- phosphoprotein binding [ISO]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated calcium channel activity [ISO]
- voltage-gated cation channel activity [ISO]
- voltage-gated ion channel activity [ISO]
- voltage-gated sodium channel activity [ISO]
Gene Ontology Cellular Component
- basal cortex [IDA, ISO]
- basal plasma membrane [ISO]
- cell-cell junction [IDA]
- ciliary basal body [IDA, ISO]
- cilium [IDA, IMP]
- cytoplasm [IDA, ISO]
- cytosol [IMP]
- endoplasmic reticulum [IDA, IMP, ISO, TAS]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- integral component of cytoplasmic side of endoplasmic reticulum membrane [ISO]
- integral component of lumenal side of endoplasmic reticulum membrane [ISO]
- integral component of plasma membrane [ISO]
- lamellipodium [ISO]
- membrane [ISO]
- mitotic spindle [IDA, ISO]
- motile primary cilium [IDA]
- nonmotile primary cilium [IDA]
- plasma membrane [IDA, ISO]
- polycystin complex [IDA]
Mus musculus
PREY
DOCK2
AI662014, AW122239, CED-5, Hch, MBC, RP23-32J15.2
dedicator of cyto-kinesis 2
GO Process (16)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- T cell activation [IMP]
- T cell proliferation [IMP]
- alpha-beta T cell activation [IMP]
- alpha-beta T cell proliferation [IMP]
- chemotaxis [IMP]
- cytoskeleton organization [IDA]
- establishment of T cell polarity [IMP]
- immunological synapse formation [IMP]
- macropinocytosis [IMP]
- membrane raft polarization [IMP]
- myeloid dendritic cell activation involved in immune response [IMP]
- negative thymic T cell selection [IMP]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of Rac protein signal transduction [IC]
- positive regulation of phagocytosis [IMP]
- positive thymic T cell selection [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.718 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID