BAIT
YAP1
AI325207, Yap, Yap65, Yki, Yorkie
yes-associated protein 1
GO Process (30)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- cell morphogenesis [IMP]
- cell proliferation [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to gamma radiation [ISO]
- cellular response to retinoic acid [IDA]
- contact inhibition [ISO]
- embryonic heart tube morphogenesis [IGI]
- hippo signaling [IGI]
- keratinocyte differentiation [IGI, IMP]
- lateral mesoderm development [IGI]
- negative regulation of epithelial cell differentiation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IGI]
- negative regulation of nucleic acid-templated transcription [ISO]
- negative regulation of stem cell differentiation [IDA]
- notochord development [IGI]
- paraxial mesoderm development [IGI]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of organ growth [IDA]
- positive regulation of stem cell maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of cell proliferation [IGI]
- regulation of keratinocyte proliferation [IMP]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of stem cell proliferation [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [IPI]
- somatic stem cell maintenance [IDA]
- transcription from RNA polymerase II promoter [IPI]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- chromatin binding [IDA]
- proline-rich region binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
Mus musculus
PREY
DROSHA
1110013A17Rik, AI874853, Etohi2, Rn3, Rnasen
drosha, ribonuclease type III
GO Process (9)
GO Function (5)
GO Component (0)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [ISO]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, ISO]
- defense response to Gram-negative bacterium [ISO]
- defense response to Gram-positive bacterium [ISO]
- miRNA metabolic process [IMP]
- pre-miRNA processing [IDA]
- primary miRNA processing [ISO]
- regulation of gene expression [IMP]
- regulation of miRNA metabolic process [IMP]
Gene Ontology Molecular Function
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.839 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID