NDEL1
Gene Ontology Biological Process
- activation of Cdc42 GTPase activity [IDA]
- canonical Wnt signaling pathway [IMP]
- cell migration [IMP]
- central nervous system neuron axonogenesis [IMP]
- centrosome localization [IMP]
- cerebral cortex radially oriented cell migration [IMP]
- chromosome segregation [IBA, ISO]
- establishment of chromosome localization [IBA]
- establishment of mitotic spindle orientation [IBA]
- inner cell mass cell proliferation [IMP]
- microtubule cytoskeleton organization [IGI]
- microtubule nucleation [IBA]
- mitotic centrosome separation [IGI, IMP]
- neurofilament cytoskeleton organization [IMP]
- neuron migration [IGI]
- neuron projection development [ISO]
- neuron projection extension [IGI]
- nuclear envelope disassembly [ISS]
- positive regulation of axon extension [ISO]
- positive regulation of axon regeneration [ISO]
- proteolysis [ISO]
- regulation of neuron projection development [IMP, ISO]
- retrograde axon cargo transport [IDA]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DYNC1H1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.934 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NDEL1 DYNC1H1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| NDEL1 DYNC1H1 | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | Low | - | BioGRID | - |
Curated By
- BioGRID