BAIT
PRKCA
AI875142, Pkca, RP23-145G23.2
protein kinase C, alpha
GO Process (51)
GO Function (7)
GO Component (18)
Gene Ontology Biological Process
- cellular calcium ion homeostasis [IMP]
- cellular response to carbohydrate stimulus [IDA]
- central nervous system neuron axonogenesis [ISO]
- chondrocyte differentiation [IDA]
- desmosome assembly [ISO]
- histone H3-T6 phosphorylation [ISO]
- inactivation of MAPK activity [IMP]
- induction of positive chemotaxis [IMP]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway [IMP]
- learning or memory [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of glucose import [IMP]
- negative regulation of heart contraction [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IGI, IMP]
- negative regulation of translation [ISO]
- neutrophil chemotaxis [IMP]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of dense core granule biogenesis [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of exocytosis [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [ISO]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synapse assembly [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of muscle contraction [IMP]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- regulation of platelet aggregation [IMP, ISO]
- regulation of receptor-mediated endocytosis [ISO]
- regulation of the force of heart contraction [IMP]
- response to estradiol [ISO]
- response to ethanol [ISO]
- response to interleukin-1 [ISO]
- response to reactive oxygen species [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [IDA]
- cell [IMP]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrion [IDA, ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- photoreceptor outer segment [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
Mus musculus
PREY
GJA1
AU042049, AW546267, Cnx43, Cx43, Cx43alpha1, Gja-1, Npm1, connexin43
gap junction protein, alpha 1
GO Process (58)
GO Function (10)
GO Component (24)
Gene Ontology Biological Process
- ATP transport [ISO]
- adult heart development [IMP]
- apoptotic process [ISO]
- atrial ventricular junction remodeling [IGI]
- blood vessel morphogenesis [IMP]
- cardiac conduction [IMP]
- cell communication [ISO]
- cell communication by chemical coupling [IDA]
- cell communication by electrical coupling [IDA, ISO]
- cell-cell junction organization [IMP]
- cell-cell signaling [IDA, ISO]
- chronic inflammatory response [ISO]
- embryonic digit morphogenesis [IMP]
- embryonic heart tube development [IMP]
- epicardial cell to mesenchymal cell transition [TAS]
- epithelial cell maturation [IMP]
- establishment of epithelial cell polarity [TAS]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- lens development in camera-type eye [IMP]
- milk ejection [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of wound healing [ISO]
- neuron migration [IMP]
- neuron projection morphogenesis [ISO]
- osteoblast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [ISO]
- positive regulation of cell communication by chemical coupling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glomerular filtration [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of striated muscle tissue development [IMP]
- positive regulation of vasoconstriction [ISO]
- positive regulation of vasodilation [ISO]
- protein oligomerization [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of blood vessel remodeling [TAS]
- regulation of bone mineralization [IMP]
- regulation of bone remodeling [IMP]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
- regulation of tight junction assembly [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [IGI, IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IGI, IMP]
- response to pH [ISO]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [IDA]
- transmembrane transport [IDA, ISO]
- vascular transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- apical plasma membrane [IDA]
- cell junction [IDA]
- cell-cell junction [IDA]
- connexon complex [ISO]
- contractile fiber [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- early endosome [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- intercalated disc [IDA, ISO]
- intermediate filament [IDA]
- late endosome [ISO]
- lateral plasma membrane [IDA]
- lysosome [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- mitochondrial outer membrane [ISO]
- multivesicular body [ISO]
- plasma membrane [IDA, ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.862 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID