BAIT
PRKCE
5830406C15Rik, PKC[e], PKCepsilon, Pkce, R75156
protein kinase C, epsilon
GO Process (36)
GO Function (13)
GO Component (13)
Gene Ontology Biological Process
- TRAM-dependent toll-like receptor 4 signaling pathway [IMP]
- cellular response to ethanol [IGI]
- cellular response to hypoxia [IDA]
- cellular response to prostaglandin E stimulus [IDA]
- chemosensory behavior [TAS]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [IMP]
- locomotory exploration behavior [IGI]
- macrophage activation involved in immune response [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of mitochondrial calcium ion concentration [ISO]
- negative regulation of mitochondrial membrane potential [ISO]
- negative regulation of release of sequestered calcium ion into cytosol [ISO]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IDA, IMP]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell-substrate adhesion [IGI, IMP]
- positive regulation of cellular glucuronidation [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of fibroblast migration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of lipid catabolic process [IMP]
- positive regulation of mucus secretion [IMP]
- positive regulation of receptor activity [IDA]
- positive regulation of synaptic transmission, GABAergic [IMP]
- positive regulation of wound healing [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- regulation of lipid metabolic process [IMP]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- regulation of release of sequestered calcium ion into cytosol [IDA]
- release of sequestered calcium ion into cytosol [IMP]
- response to morphine [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- SH3 domain binding [ISO]
- actin monomer binding [IDA]
- calcium-independent protein kinase C activity [IDA]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [IDA]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- receptor activator activity [IDA]
- receptor binding [ISO]
- 14-3-3 protein binding [IPI]
- SH3 domain binding [ISO]
- actin monomer binding [IDA]
- calcium-independent protein kinase C activity [IDA]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [IDA]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- receptor activator activity [IDA]
- receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
GJA1
AU042049, AW546267, Cnx43, Cx43, Cx43alpha1, Gja-1, Npm1, connexin43
gap junction protein, alpha 1
GO Process (58)
GO Function (10)
GO Component (24)
Gene Ontology Biological Process
- ATP transport [ISO]
- adult heart development [IMP]
- apoptotic process [ISO]
- atrial ventricular junction remodeling [IGI]
- blood vessel morphogenesis [IMP]
- cardiac conduction [IMP]
- cell communication [ISO]
- cell communication by chemical coupling [IDA]
- cell communication by electrical coupling [IDA, ISO]
- cell-cell junction organization [IMP]
- cell-cell signaling [IDA, ISO]
- chronic inflammatory response [ISO]
- embryonic digit morphogenesis [IMP]
- embryonic heart tube development [IMP]
- epicardial cell to mesenchymal cell transition [TAS]
- epithelial cell maturation [IMP]
- establishment of epithelial cell polarity [TAS]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- lens development in camera-type eye [IMP]
- milk ejection [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of wound healing [ISO]
- neuron migration [IMP]
- neuron projection morphogenesis [ISO]
- osteoblast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [ISO]
- positive regulation of cell communication by chemical coupling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glomerular filtration [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of striated muscle tissue development [IMP]
- positive regulation of vasoconstriction [ISO]
- positive regulation of vasodilation [ISO]
- protein oligomerization [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of blood vessel remodeling [TAS]
- regulation of bone mineralization [IMP]
- regulation of bone remodeling [IMP]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
- regulation of tight junction assembly [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [IGI, IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IGI, IMP]
- response to pH [ISO]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [IDA]
- transmembrane transport [IDA, ISO]
- vascular transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- apical plasma membrane [IDA]
- cell junction [IDA]
- cell-cell junction [IDA]
- connexon complex [ISO]
- contractile fiber [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- early endosome [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- intercalated disc [IDA, ISO]
- intermediate filament [IDA]
- late endosome [ISO]
- lateral plasma membrane [IDA]
- lysosome [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- mitochondrial outer membrane [ISO]
- multivesicular body [ISO]
- plasma membrane [IDA, ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.753 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID