BAIT
EPS8
AW261790
epidermal growth factor receptor pathway substrate 8
GO Process (12)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- Rac protein signal transduction [IDA]
- actin crosslink formation [IDA, IMP]
- actin cytoskeleton reorganization [IMP]
- actin filament bundle assembly [IDA, IGI, IMP]
- actin polymerization-dependent cell motility [IDA]
- adult locomotory behavior [IMP]
- barbed-end actin filament capping [IDA, IMP]
- behavioral response to ethanol [IMP]
- dendritic cell migration [IMP]
- exit from mitosis [IMP]
- regulation of actin filament length [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GLI2
AW546128
GLI-Kruppel family member GLI2
GO Process (59)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- anatomical structure development [IGI, IMP]
- anatomical structure formation involved in morphogenesis [IGI]
- axon guidance [IMP]
- branching morphogenesis of an epithelial tube [IMP]
- cell differentiation [IMP]
- cell proliferation [IGI, ISO]
- cellular response to organic cyclic compound [IDA]
- cellular response to virus [ISO]
- cerebellar cortex morphogenesis [IGI, IMP]
- chondrocyte differentiation [IGI]
- cochlea morphogenesis [IMP]
- developmental growth [IMP]
- dorsal/ventral neural tube patterning [IDA, IMP]
- dorsal/ventral pattern formation [IGI]
- embryonic digestive tract development [IMP]
- embryonic digit morphogenesis [IMP]
- epidermal cell differentiation [ISO]
- floor plate formation [IMP]
- head development [IMP]
- heart development [IGI]
- hindbrain development [IGI, IMP]
- hindgut morphogenesis [IGI, IMP]
- in utero embryonic development [IMP]
- kidney development [IGI]
- lung development [IGI, IMP]
- mammary gland development [IMP]
- mammary gland duct morphogenesis [IMP]
- morphogenesis of an epithelium [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- neural tube development [IMP]
- neuron development [IMP]
- notochord regression [IGI]
- odontogenesis of dentin-containing tooth [IGI, IMP]
- osteoblast development [IDA, IMP]
- osteoblast differentiation [IGI, ISO]
- pattern specification process [IGI, IMP]
- pituitary gland development [IGI]
- positive regulation of DNA replication [ISO]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of neuron differentiation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- prostatic bud formation [IMP]
- proximal/distal pattern formation [IGI]
- regulation of smoothened signaling pathway [IMP]
- skeletal system development [IMP]
- smoothened signaling pathway [IGI, IMP, ISO]
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [IGI, IMP]
- smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [IGI]
- smoothened signaling pathway involved in ventral spinal cord interneuron specification [IGI]
- spinal cord dorsal/ventral patterning [IGI, IMP]
- spinal cord motor neuron differentiation [IMP]
- spinal cord ventral commissure morphogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- tube development [IGI]
- ventral midline development [IGI, IMP]
- ventral spinal cord development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.703 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID