BAIT
GRM7
6330570A01Rik, BB176677, C030018L03, E130018M02Rik, Gpr1g, Gprc1g, mGluR7
glutamate receptor, metabotropic 7
GO Process (20)
GO Function (13)
GO Component (21)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IBA, ISO, TAS]
- adult behavior [IMP]
- associative learning [IMP]
- behavioral fear response [IMP]
- calcium ion transmembrane transport [IDA]
- conditioned taste aversion [IMP]
- memory [IMP]
- multicellular organismal response to stress [IMP]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cAMP biosynthetic process [ISO]
- negative regulation of glutamate secretion [ISO]
- neurological system process [IMP]
- regulation of cyclase activity [ISO]
- regulation of ion transmembrane transport [IDA]
- regulation of neuron death [TAS]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of sound [ISO]
- short-term memory [IMP]
- synaptic transmission [IDA, ISO]
- transmission of nerve impulse [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO, TAS]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [ISO]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IDA]
- calcium ion binding [ISO]
- calcium-dependent protein binding [ISO]
- calmodulin binding [ISO]
- glutamate binding [ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IBA, ISO, TAS]
- protein homodimerization activity [ISO]
- serine binding [ISO]
- voltage-gated calcium channel activity [IDA]
- PDZ domain binding [ISO, TAS]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [ISO]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IDA]
- calcium ion binding [ISO]
- calcium-dependent protein binding [ISO]
- calmodulin binding [ISO]
- glutamate binding [ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IBA, ISO, TAS]
- protein homodimerization activity [ISO]
- serine binding [ISO]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- asymmetric synapse [ISO]
- axon [ISO]
- axon terminus [ISO]
- cell cortex [ISO]
- cell surface [ISO]
- dendrite [ISO]
- dendritic shaft [ISO]
- integral component of membrane [ISO]
- integral component of plasma membrane [IBA]
- membrane [ISO]
- neuronal cell body [ISO]
- postsynaptic membrane [ISO]
- presynaptic active zone [ISO]
- presynaptic active zone membrane [TAS]
- presynaptic membrane [IDA, ISO]
- protein complex [ISO]
- receptor complex [ISO]
- rough endoplasmic reticulum [ISO]
- synapse [ISO]
- terminal bouton [ISO]
Mus musculus
PREY
GRM4
Gprc1d, mGluR4
glutamate receptor, metabotropic 4
GO Process (5)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.825 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID