BAIT
GRM1
4930455H15Rik, ENSMUSG00000075319, Gm10828, Gprc1a, mGluR1, nmf373, rcw, wobl
glutamate receptor, metabotropic 1
GO Process (15)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO]
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [IDA]
- activation of MAPKK activity [IDA]
- calcium-mediated signaling [ISO]
- cellular response to electrical stimulus [IMP]
- dimeric G-protein coupled receptor signaling pathway [ISO]
- locomotory behavior [IMP]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA]
- regulation of MAPK cascade [IDA]
- regulation of sensory perception of pain [IDA]
- regulation of synaptic transmission, glutamatergic [IBA, ISO]
- sensory perception of pain [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- G-protein coupled receptor dimeric complex [ISO]
- G-protein coupled receptor homodimeric complex [ISO]
- axon [ISO]
- cytosol [ISO]
- dendrite [IDA]
- dendritic spine [ISO]
- integral component of plasma membrane [IBA, ISO]
- intracellular [ISO]
- neuron projection [IDA]
- neuronal cell body [TAS]
- nucleus [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [TAS]
- presynaptic membrane [ISO]
Mus musculus
PREY
GRM5
6430542K11Rik, AI850523, Glu5R, Gprc1e, mGluR5, mGluR5b
glutamate receptor, metabotropic 5
GO Process (15)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO]
- activation of MAPKKK activity [ISO]
- cognition [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [ISO]
- learning [IMP]
- locomotory behavior [IGI, IMP]
- negative regulation of locomotion [ISO]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of long-term neuronal synaptic plasticity [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA, ISO]
- protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of synaptic transmission, glutamatergic [IBA]
- regulation of transcription, DNA-templated [ISO]
- synaptic transmission [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.892 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID