BAIT
FXN
FA, FARR, Frda, X25
frataxin
GO Process (25)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- adult walking behavior [IMP]
- aerobic respiration [IMP]
- cellular iron ion homeostasis [IMP, ISO]
- cellular response to hydrogen peroxide [ISO]
- embryo development ending in birth or egg hatching [IMP]
- iron incorporation into metallo-sulfur cluster [ISO]
- iron-sulfur cluster assembly [IMP]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of multicellular organism growth [IMP]
- negative regulation of organ growth [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- oxidation-reduction process [ISO]
- oxidative phosphorylation [IMP]
- positive regulation of axon extension [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of lyase activity [ISO]
- positive regulation of metalloenzyme activity [ISO]
- positive regulation of oxidoreductase activity [ISO]
- positive regulation of transferase activity [ISO]
- proprioception [IMP]
- protein autoprocessing [ISO]
- regulation of ferrochelatase activity [ISO]
- response to iron ion [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
HSPD1
60kDa, Hsp60
heat shock protein 1 (chaperonin)
GO Process (24)
GO Function (11)
GO Component (23)
Gene Ontology Biological Process
- B cell activation [ISO]
- B cell cytokine production [ISO]
- B cell proliferation [ISO]
- MyD88-dependent toll-like receptor signaling pathway [ISO]
- T cell activation [IDA, IGI, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- chaperone mediated protein folding requiring cofactor [ISO]
- detection of misfolded protein [ISO]
- isotype switching to IgG isotypes [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of T cell activation [IDA, ISO]
- positive regulation of T cell mediated immune response to tumor cell [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-alpha production [IDA, ISO]
- positive regulation of interferon-gamma production [IDA, IGI, ISO]
- positive regulation of interleukin-10 production [ISO]
- positive regulation of interleukin-12 production [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of macrophage activation [ISO]
- protein refolding [ISO]
- protein stabilization [ISO]
- response to unfolded protein [ISO]
Gene Ontology Molecular Function- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [ISO]
- lipopolysaccharide binding [IDA, ISO]
- misfolded protein binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [ISO]
- lipopolysaccharide binding [IDA, ISO]
- misfolded protein binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell surface [ISO]
- coated pit [ISO]
- coated vesicle [ISO]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- lipopolysaccharide receptor complex [ISO]
- membrane [ISO]
- membrane raft [ISO]
- mitochondrial crista [ISO]
- mitochondrial inner membrane [IDA]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
- secretory granule [IDA, ISO]
- zymogen granule [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.91 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID